Stan Harbinger (Joe Pantoliano) is a top-rated talk show host with a flair for the outrageous and a reputation as a skeptic's skeptic. Assisted by his producer Trudy (Cynthia Nixon), Stan takes special delight in shooting down callers who claim to have alien encounters, especially people like Eldon DeVries (Alan Zinyk), who believes his body has been taken over by aliens. However, when Eldon commits suicide by setting himself on fire in front of Stan, things begin to go wrong for Stan. A plan to syndicate the show is threatened by protests from UFO believers, angry at Stan's role in Eldon's death.